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At least half of North American adults have been infected by parvovirus B19 and are Homeopathic Remedies for Fifth Disease - Slapped Cheek Syndrome. May 2, - Fifth Disease (Human parvovirus/Erythema Infectiosum) is a minor, contagious viral illness that commonly affects children aged 5 to 15 years. Fifth Disease symptoms include a rapid onset of a warm, red rash that first appears on the cheeks, then threads to the trunk, arms and legs.