Feb 6, - SSRIs have been found to cut a man's sperm count as well as the normal shape and motility of their sperm by 50 percent. As it is, chronic stress and depression can lower a man's level of testosterone, which in turn can decrease his sperm count. Effects of amitriptyline on semen of infertile men. A clinical evaluation of the effects of the antidepressive drug amitriptyline on the semen of 20 infertile men with oligoasthenozoospermia was carried out. It would seem that amitriptyline has a beneficial effect on semen in some of these patients.